AB-CHMINACA


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AB-CHMINACA – Chemical Structural Data

AB-CHMINACA is an indole based synthetic cannabinoid. It has a cyclohexyl group substituted for the 4-fluorophenyl group as seen in it’s chemical cousin AB-FUBINACA. As part of its structure, much like other synthetic cannabinoids seen in its generation, it contains a valine amino acid amide residue rather than the more classically seen naphthyl or adamantine residue.

AB-CHMINACA – Structure-Activity & Chemical Similarity Predictions

Based on the animal studies available, AB-CHMINACA is highly potent and able to cause psychological effects similar to the THC within herbal marijuana. As a potent agonist at the CB1 receptor and CB2 receptor with Ki values of 0.78 nM and 0.45 nM respectively, it is 16 more potent than THC.

Known Chemical Data

Systematic (IUPAC) name N-[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]-1-(cyclohexylmethyl)indazole-3-carboxamide
Chemical Name AB-CHMINACA
Identifiers
CAS Number 1185887-21-1
ATC code
PubChem 44206133
ChemSpider 30646774
Chemical data
Formula C20H28N4O2
Molar mass 356.46 g/mol
Online Synonyms
  1. AB-CHMINACA
  2. N-(1-(aminocarbonyl)-2-methylpropyl)-1-(cyclohexylmethyl)-1H-indazole-3-carboxamide
  3. N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-1H-indazole-3-carboxamide
  4. AB-CHMINACA
  5. Ab-chminaca, (+/-)-
  6. SCHEMBL13691214
  7. J3.369.872K
  8. N-(1-Amino-3-methyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-1H-indazole-3-carboxamide
  9. 1805788-79-7

 

AB-CHMINACA – Discovery, History & Research

Discovery

The official patent which would cover the discovery of AB-CHMINACA would be that of Pfizer’s application in February 2009 when patent number WO2009106980 A2 was first described in the literature and later published in September 2009.

History

Since its documentation in the above mentioned patent there has been much discussion of its use in the scientific community and non-scientific community also. Some studies exist with the use of AB-CHMINACA in vivo on mice, with further documented toxicology reports. Since its discussion began around 2009, its steadily gained popularity as a potent synthetic cannabinoid. Finally, as the legal community began to see AB-CHMINACA deaths the research chemical has become controlled and scheduled in many countries including, USA, Germany, China, and Switzerland in 2015.

Research

AB-CHMINACA has some very interesting studies into its binding affinity in rate, which is rarely seen on novel compounds. It has been found to be extremely potent and fully replace THC as a substitute. Furthermore, research into it’s illicit use has been conducted in various toxicolocy reports after several deaths were reported around the world.

Some of the more notable research papers can be found below.

26105953

26154784

26257317

26555732

26890319

25730924

“关于印发《非药用类麻醉药品和精神药品列管办法》的通知”

 

Key Areas of Research

Samples of AB-CHMINACA to purchase online may be used in the following scientific applications.  

  • As a forensic sample and/or for forensic chemical catalogues.
  • As a reference sample for Toxicology laboratories.
  • As a chemical reagent and/or intermediate
  • Pharmaceutical Intermediate
  • As a research chemical sample within studying pharmacology of receptor binding assays.
  • Affinity and Efficacy Receptor profiling specifically at the CB1 and CB2 receptors.
  • Reference sample for the application within future therapeutic compounds
  • Pure reference standard for chemical analytical libraries using HPLC, FTIR, NMR and GC/MS equipment

AB-CHMINACA – Online Anecdotal Reports

Since various AB-CHMINACA deaths have been reported, great caution should be taken when reading about anecdotal AB-CHMINACA reviews and experiences online. The DEA have changed the AB-CHMINACA legality with many other countries following suit and banning it sale.

Nonetheless, it has been available in various countries as a research chemical and AB-CHMINACA reddit, erowid and other prominent forum discussions exist.

Forum links to anecdotal discussion by those who are able to buy AB-CHMINACA online.

Reddit.com

Erowid.org

BlueLight.org

drugs-forum.com

ukchemicalresearch.org

Chemical Safety, Legality & Indented Use

Intended use

This is a research chemical compound. Sold as an analytical standard, reagent or laboratory tool for in vitro (outside a living organism) research only. This compound is not for human consumption or any form or in vivo research.

Legality

It is the sole responsibility of the purchaser to ensure this compound is legal to purchase and import for research chemical purposes in their country.

Chemical Safety

This compound is intended to be used in strict laboratory conditions, following all proper precautionary protocol for any novel and untested chemical. The toxicological and physiological action of this compound have not been assessed and so extreme caution should be observed when handling this compound. Please follow proper health and safety guidelines, in a well ventilated and well equipped laboratory when handling this compound.

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