Chemical Structural Data

As part of the diarylethylamine chemical class, Diphenidine has a substituted phenethylamine skeleton and an interesting additional phenyl ring bound to the Rα. Within the piperidine ring is a terminal amino group which would be a member of the phenethylamine chain – group. This means that Diphenidine is technically part of the piperidine dissociative class of compound.

Structure – Activity & Chemical Similarity Predictions

As a dissociative chemical with structural similarity to Methoxphenidine, Diphenidine is lacking the 2-methoxy substitution on the phenyl ring.

Diphenidine would act as a normal NMDA receptor antagonist, however, some online reports have stated there maybe some dopamine, serotonin or even opiate action to this compound.

There has not been any official receptor affinity testing at these receptors so any talk of this action is purely based on subjective hypothesise or anecdotal chemical predictions.

There is some talk of Diphenidine being a strong NMDA receptor antagonist during neurogenesis. However, this is yet to be established in publications.

Known Chemical Data

Systematic (IUPAC) name (±)-1-(1,2-Diphenylethyl)piperidine
Chemical Name


CAS Number 36794-52-2
ATC code
PubChem 206666
ChemSpider 179031
Chemical data
Formula C19H23N
Molar mass 265.39 g/mol
Online Synonyms 1,2-DEP DPD







Piperidine, 1-(1,2-diphenylethyl)-




Discovery, History & Research Chemical data


Interestingly Diphenidine was actually first ever described as early as 1924 when Christiaen -conducting a reaction to similar to the Maddox reaction used to first synthesise PCP – was using it for a Brulyants reaction.

However, much like many other 1,2-diarylethylamine’s being research at the time, Diphenidine was actually described as part of the same patent seen for Methoxphenidine back in the publication of the patent as early as 1994.

Below is a list of the names inventors for patent Application number EP19890110572. The publication of this patent was April 6th 1994.

Inventors: Nancy M. Gray, Brian K. Cheng


Since the first discussion of its use within the above patent, Diphenidine has been sold online as part of the growing dissociative group of research chemicals. As a close relative to Methoxphenidine and other diarylethylamines, Diphenidine has been described as a dissociative anaesthetic and was actually introduced into the grey area market shortly after the UK arylcyclohexylamines ban back in 2013. Diphenidine was later found to be combined within online “herbal incense” blends in Japan mixed alongside synthetic cannabinoids.

Chemical Research

Researched as an investigative medicine, it does have some history of both in vivo and in-vitro use as an NMDA receptor antagonist and as an investigative treatment for neurotoxic injury. Interestingly, Diphenidine research has shown that it acts on the dopamine transporter, unlike related compounds. Diphenidine has been found in Electrophysiological studies to have a reduced amplitude NMDA-mediated fEPSPs than that of Ketamine with a markedly slower onset of action. Further, research in 2016 found that Diphenidine does, in fact have some small affinity for the σ1 receptor, σ2 receptor dopamine transporter.

Below is a curated list of some of the most notable Diphenidine research publications:



Key Areas of Research

Samples of Diphenidine to purchase online may be used in the following scientific applications.  

  • As a forensic sample and/or for forensic chemical catalogs.
  • As a reference sample for Toxicology laboratories.
  • As a chemical reagent and/or intermediate
  • Pharmaceutical Intermediate
  • As a research chemical sample within studying pharmacology of receptor binding assays.
  • Effinity and Efficacy Receptor profiling.
  • Reference sample for the application within future therapeutic compounds
  • Pure reference standard for chemical analytical libraries using HPLC, FTIR, NMR and GC/MS equipment

Online Anecdotal Reports

Diphenidine has been discussed online for those looking to discuss the anecdotal Diphenidine trip reports, experiences or subjective effects. Commonly, the online discussion has centered around Diphenidine dosage or route of administration (such as insufflation).

Other reports have looked to see if a Diphenidine drug test would identify it as a potential Ketamine analog within the blood stream.

Forum links to anecdotal discussion by those who are able to buy Diphenidine crystals online.


Chemical Safety, Legality & Indented Use

Intended use

This is a research chemical compound. Sold as an analytical standard, reagent or laboratory tool for in vitro (outside a living organism) research only. This compound is not for human consumption or any form or in vivo research.


It is the sole responsibility of the purchaser to ensure this compound is legal to purchase and import for research chemical purposes in their country.

Chemical Safety

This compound is intended to be used in strict laboratory conditions, following all proper precautionary protocol for any novel and untested chemical. The toxicological and physiological action of this compound have not been assessed and so extreme caution should be observed when handling this compound. Please follow proper health and safety guidelines, in a well ventilated and well-equipped laboratory when handling this compound.


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