Ethylphenidate


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ETHYLPHENIDATE – Chemical Structural Data

Ethylphenidate is a synthetic compound consisting of a phenethylamine core with an ethyl group attached. Structurally similar to amphetamine, Ethylphenidate features a substitution at the Rα – incorporated within the piperidine ring. Structurally speaking, Ethylphenidate differs from Methylphenidate (Ritalin) in that it has an elongated carbon chain. Ethylphenidate is thought to be produced as a chiral racemic mixture.

 

ETHYLPHENIDATE – Structure-Activity & Chemical Similarity Predictions

Based on the known in vivo action of Ritalin, and the fact that Ethylphenidate is a product of alcohol and Ritalin after co-ingestion and liver metabolism. The following receptor binding data has been described in rodent studies.

Compound Binding DAT Binding NET Uptake DA Uptake NE
d-methylphenidate 139 408 28 46
d-ethylphenidate 276 2479 24 247
dl-methylphenidate 105 1560 24 31
dl-ethylphenidate 382 4824 82 408

Ethylphenidate acts as a potent stimulant with primary affinity for the dopamine and norepinephrine receptors.

Known Chemical Data

Systematic (IUPAC) name (RS)-ethyl 2-phenyl-2-piperidin-2-ylacetate
Chemical Name Ethylphenidate

 

Identifiers
CAS Number 57413-43-1
ATC code
PubChem 3080846
ChemSpider 2338571
Chemical data
Formula C15H21NO2
Molar mass 247.33274 g/mol
Online Synonyms Ethyphenidate;thylphenidate;ethylphenidate;Ethylphenidate [57413-43-1];phenyl-piperidyl-acetic acid ethyl ester;ethyl 2-phenyl-2-piperidin-2-ylacetate HCl;2-Piperidineaceticacid, a-phenyl-, ethyl ester;alpha-Phenyl-2-piperidineacetic acid ethyl ester;Ethylphenidate 2-Piperidineaceticacid, a-phenyl-, ethyl ester

EPH

Baxtercain

Baxter

Ethylphenidate 57413-43-1 CHEMBL534479 Ethyphenidate Ethyl phenidate Phenyl-piperidin-2-yl-acetic acid ethyl ester; hydrochloride AC1MIVU6 SCHEMBL727938 CHEMBL1187932 BDBM50165211 AKOS025149438 EBD2197478 ethyl 2-phenyl-2-piperidin-2-ylacetate AK313103 HE052768 HE354966 Ethyl 2-phenyl-2-(piperidin-2-yl)acetate X5896 2-Piperidineaceticacid, a-phenyl-, ethyl ester 2-Piperidineacetic acid, alpha-phenyl-, ethyl ester S14-2940 (2R,2”R)-Phenyl-piperidin-2-yl-acetic acid ethyl ester; hydrochloride (2S,2”S)-Phenyl-piperidin-2-yl-acetic acid ethyl ester; hydrochloride

ETHYLPHENIDATE – Discovery, History & Research

Discovery

Ethylphenidate was first described in the literature as long ago as 1998 discussion of Tamoxetine in the treatment of ADHD. Some of the most relevant research was in 2005 with the “synthesis and pharmacology of ethylphenidate enantiomers”.

History

Ethylphenidate seems to have first been discussed by research and development teams within Elli lilly drug company as early as 1998. Since then, Ethylphenidate seems to have been one of the oldest known research chemicals to explode on the scene with the global online research chemical movement in 2009. Alongside, Mephedrone and Methiopropamine, Ethylphenidate was distributed online and has had extensive research conducted informally and anecdotally on its subjective effects.

Since Ethylphenidate is essentially a product of Ritalin (methylphenidate) taken in combination with Alcohol (ethanol) – so much of its effects can be characterised as a metabolite of this Co-administration.

Although not internationally controlled, Ethylphenidate has found its way into the list for banned substances after its detection in toxicology reports and other major test purchases.

As of around 2015, Ethylphenidate became illegal for purchase without a valid government licence in most western countries, including the manufacturing origin country – China.

Research

Since 1998 there have been several research papers published on the co-abuse potential of Ritalin with Alcohol, as this causes Ethylphenidate to be produced in vivo. Considering that Ritalin is a globally recognised treatment for ADHD, the scientific community has found vast funding for this harm prevention research.

Below you may find a list of the research which has been conducted over the last 20 years on Ethylphenidate. These are the PubMed identifier numbers for the studies.

20160317
20160107
20151217
20151105
20150611
20150319
20150217
20150127
20150101
20141030
20141023
20140918
20140918
20140918
20140918
20140918
20140828
20140522
20130620
20121011
20120927
20120531
20120503
20110825
20110201
20110127
20090305
20070503
20061026
20051027
20031211
20020919
20020801
19980901
19980826
19980604
19980219
19970710
19960718

 

Key Areas of Research

Samples of ETHYLPHENIDATE to purchase online may be used in the following scientific applications.  

  • As a forensic sample and/or for forensic chemical catalogues.
  • Cocaine addiction and liver metabolism of alcohol with stimulant drugs
  • Norepinephrine and dopamine receptor binding studies.
  • Primary ADHD research.
  • As a reference sample for Toxicology laboratories.
  • As a chemical reagent and/or intermediate
  • Pharmaceutical Intermediate
  • As a research chemical sample within studying pharmacology of receptor binding assays.
  • Affinity and Efficacy Receptor profiling.
  • Reference sample for the application within future therapeutic compounds
  • Pure reference standard for chemical analytical libraries using HPLC, FTIR, NMR and GC/MS equipment

ETHYLPHENIDATE – Online Anecdotal Reports

Ethylphenidate has been synthesised and produced, in bulk, from Chinese laboratories for a number of years now. Online, there has been in-depth Ethylphenidate reviews and reports, describing the subjective experiences of users who’ve bought Ethylphenidate in the USA, UK and other major research chemical hubs.

Forum links to anecdotal discussion by those who are able to buy Ethylphenidate crystals online.

Reddit.com

Erowid.org

BlueLight.org

psychonautwiki.org

drugs-forum.com

ukchemicalresearch.org

Chemical Safety, Legality & Indented Use

Intended use

This is a research chemical compound. Sold as an analytical standard, reagent or laboratory tool for in vitro (outside a living organism) research only. This compound is not for human consumption or any form or in vivo research.

Legality

It is the sole responsibility of the purchaser to ensure this compound is legal to purchase and import for research chemical purposes in their country.

Chemical Safety

This compound is intended to be used in strict laboratory conditions, following all proper precautionary protocol for any novel and untested chemical. The toxicological and physiological action of this compound have not been assessed and so extreme caution should be observed when handling this compound. Please follow proper health and safety guidelines, in a well ventilated and well equipped laboratory when handling this compound.

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